![]() CyBorD treatment was stopped when he was diagnosed with Staphylococcus epidermidis endocarditis that was treated with vancomycin followed by ampicillin-sulbactam for one month. A few central veins show partial to near complete occlusion and pericellular fibrosis.Ī 57-year-old man with kappa light chain multiple myeloma was treated for approximately two years with CyBorD. Hematoxylin and eosin-stained section of the liver biopsy shows foci of centrilobular hepatocyte drop-out, cholestasis, and portal areas with ductular reaction. Some of the bile ducts show cytoplasmic vacuolation, disordered nuclear polarity, and occasional mononuclear inflammatory infiltrates within the bile duct epithelium. ![]() Portal tracts show mild portal fibrosis and focal ductular reaction. Hematoxylin and eosin-stained section of the liver biopsy shows preserved lobular architecture with patchy fibrosis within sinusoids and marked central venular fibrosis. ![]() The hepatocyte shows dropout of hepatocytes and acidophilic bodies predominantly involving centrilobular areas with intracanalicular and intrahepatic cholestasis. Bile ducts show mild dystrophy and regenerative changes in some portal tracts. ![]() Hematoxylin and eosin-stained section of the liver biopsy shows some portal areas with sparse inflammation comprising predominantly of lymphocytes and rare plasma cells, with fibrous expansion of most portal areas. Diagnosis of SOS on liver biopsy in case 1, 2, and 3.
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